Christian Lood, PhD
Associate Professor
Division of Rheumatology
Sites of Practice: 
South Lake Union

Faculty Information

Biography
Education & Training: 
MSc in Biomedicine
Lund University
Sweden
2003-2007
PhD in Rheumatology
Lund University
Sweden
2008-2012
Postdoctoral Associate
Lund University
Sweden
2012-2013
Visiting Scientist
University of Washington
Seattle, WA
2013-2016
Contact
Phone: 
(206) 221-8446
Mailing Address: 

750 Republican Street
Box 358060
Seattle, WA 98109

Lood Lab

Research & Clinical Interests
Research Interests: 

Dr. Christian Lood studies the role of neutrophils in inflammation and autoimmunity with an emphasis on the contribution of neutrophils to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) pathogenesis. Neutrophils are the main immune cells in the circulation, participating in host defense through mechanisms including production of reactive oxygen species (ROS), phagocytosis and formation of neutrophil extracellular traps (NETs), a recently identified neutrophil cell death process in which DNA is extruded together with cytoplasmic and granular content to trap and eliminate extracellular pathogens. Although beneficial from a host-pathogen perspective, exaggerated neutrophil activation and NET formation has been linked to autoimmunity, in particular SLE and RA.

Dr. Lood’s Lab is currently pursuing three main research aims, a) assessing how neutrophil-derived mitochondria and mitochondrial DNA are cleared to avoid unwarranted inflammation and autoimmunity, b) investigating the interplay between TLR8 and FcgRIIA in skewing neutrophils towards an inflammatory phenotype and c) identifying novel neutrophil- and mitochondrial-derived biomarkers related to disease activity and severity, including cardiovascular disease, a leading cause of mortality in young SLE women.

Publications
Publications: 

Selected-

Duvvuri B, Pachman LM, Morgan G, Khojah AM, Klein-Gitelman M, Curran ML, Doty S, Lood C. Neutrophil extracellular traps in tissue and periphery in juvenile dermatomyositis. Arthritis Rheum 2020;72:348-358.

Bach M, Moon J, Moore R, Pan T, Nelson JL, Lood C. A neutrophil activation biomarker panel in prognosis and monitoring of patients with rheumatoid arthritis. Arthritis Rheum 2020;72:47-56.

Duvvuri B, Lood C. Cell-free DNA as a biomarker in autoimmune rheumatic diseases. Front Immunol 2019;10:502.

Lood C, Arve S, Ledbetter J, Elkon KB. TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA. J Exp Med 2017;214:2103-2119.

Lood C, Hughes GC. Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity. Rheumatology 2017;56:638-643.

Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med 2016;2:146-53.