Dr. Hughes
Associate Professor
Division of Rheumatology
Section Head, Harborview Medical Center
Fellowship Program Director
Robert F. Willkens, M.D. - Lucile T. Henderson Endowed Professor in Rheumatology
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information

Education & Training: 
Fulbright Scholar
University of Oslo
Oslo, Norway
Oregon Health and Sciences University
Portland, OR
Internal Medicine Residency
University of Washington
Seattle WA
University of Washington
Seattle WA
Acting Instructor, Post-doctoral fellow
University of Washington
Seattle WA
(206) 543-3414
Research & Clinical Interests
Research Interests: 

 Female reproductive hormones and lupus autoimmunity.



Lood C, Hughes GC. Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity. Rheumatology (Oxford). 2016 Jun 27. pii.kew256.

Gazitt T, Thomason J, Hughes GC. The Reply. Am J Med. 2016 Jan;129(1):e19. doi: 10.1016/j.amjmed.2015.09.003. No abstract available. PMID: 26703010

Tsur A, Hughes GC, Schoenfeld Y.  Interdisciplinary exchange of ideas: progestagens for autoimmunity, biologics for pregnancy complications.  Immunol Res 2015;61:31-4.

Wong A, Agrawal N, Hughes GC.  The nuclear progesterone receptor regulates IgG2c autoantibodies, T follicular helper  and regulator T cells in lupus-prone Nba2 mice.  Autoimmunity2015;10:1-13.

Hughes GC, Choubey D.  Modulation of autoimmune rheumatic diseases by oestrogen and progesterone.  Nat Rev Rheumatol 2014 Aug 26. doi: 10.1038/nrrheum.2014.144. [Epub ahead of print]

Hughes GC, Clark EA, Wong AH. The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses. J Leukoc Biol. 2013 Mar;93(3):369-75. doi: 10.1189/ jlb.1012491.

Hughes GC. Progesterone and autoimmune disease. Autoimmun Rev. 2012 May;11(6-7): A502-14. Epub 2011 Dec 13.

Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice. Arthritis Rheum. 2009 Jun;60(6):1775-84.

Hughes GC, Thomas S, Li C, Kaja M, Clark EA. Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells. J Immunol 2008;180:2029-2033.

Martin DA, Zhang K, Kenkel J, Hughes G, Clark E, Davidson A, Elkon KB. Autoimmunity stimulated by adoptively transferred dendritic cells is initiated by both ab and gd T-cells but does not require MyD88 signaling. J Immunol 2007;179:5819-5828.

Hughes GC, Clark EA. Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity. Autoimmunity 2007;40:470-481.