Dr. Hughes
Associate Professor
Division of Rheumatology
Section Head, Harborview Medical Center
Fellowship Program Director
Robert F. Willkens, M.D. - Lucile T. Henderson Endowed Professor in Rheumatology
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information

Biography
Education & Training: 
Fulbright Scholar
University of Oslo
Oslo, Norway
1995-1996
MD
Oregon Health and Sciences University
Portland, OR
2001
Internal Medicine Residency
University of Washington
Seattle WA
2001-2002
Fellowship
University of Washington
Seattle WA
2003-2005
Acting Instructor, Post-doctoral fellow
University of Washington
Seattle WA
2005-2009
Contact
Email: 
Phone: 
(206) 543-3414
Research & Clinical Interests
Research Interests: 
  • Medical Education
  • Equity, Diversity and Inclusion in Rheumatology
  • Health Equity Research
Publications
Publications: 

Selected

  1. Hughes GC, Thomas S, Li C, Kaja M, Clark EA.  Progesterone regulates interferon-alpha production by plasmacytoid dendritic cells.  J Immunol 2008;180:2029-2033.
  2. Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark, EA, Elkon KB.  Decrease in Glomerulonephritis and Th1-Associated Autoantibody Production After Progesterone Treatment in NZB/NZW Mice.  Arthritis Rheum 2009;60:1775-84
  3. Hughes GC, Choubey D.  Modulation of autoimmune rheumatic diseases by oestrogen and progesterone.  Nat Rev Rheumatol 2014 Aug 26. doi: 10.1038/nrrheum.2014.144. [Epub ahead of print]
  4. Lood C, Hughes GC.  Neutrophil extracellular traps as a potential souce of autoantigen in cocaine-assocaited autoimmunity.  Rheumatology 2017.  PMID: 27354687
  5. Morcos M, Lood C, Hughes G.  Demographic, clinical and immunologic correlates among a cohort of 50 cocaine users demonstrating anti-neutrophil cytoplasmic antibodies. J Rheumatol. 2019 Sep;46(9):1151-1156. PMID: 31092720
  6. Thomason J, Lood C, Obih U, Koelle D, Hughes G. An interferon gamma release assay as a novel biomarker in systemic lupus erythematosus. Rheumatology 2020. PMID: 32375180.
  7. Griffin G, Shenoi S, Hughes G. Hemophagocytic lymphohistiocyotis syndrome: update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol 2020. PMID: 32387063.
  8. Da Mota LMH, Hughes GC. Not so elementary: Uncommon inflammatory, autoimmune, and infectious diseases encountered by the rheumatologist. Best Pract Res Clin Rheumatol 2020 PMID: 33129441
  9. Thomason J, Bays A, Mantilla B, Huang I, Najjar R, Singh N, Wysham K, Hughes G. Non-English Language Preference Associated with Decreased Rheumatology Telehealth Utilization During the COVID-19 Pandemic. Arthritis and Rheumatology Open. 2022. PMID: 35084116