Jane Buckner, MD

Affiliate Professor

Division of Rheumatology

President, Benaroya Research Institute at Virginia Mason

Program Director, Translational Research Program

Faculty Information

Biography

Education & Training:

The John Hopkins University School of Medicine

Baltimore, MD

1984-1987

Residency in Internal Medicine

University of Minnesota

Minneapolis, MN

1987-1990

Chief Residency in Internal Medicine

University of Minnesota

Minneapolis, MN

1990-1991

Fellowship, Rheumatology

University of Minnesota

Minneapolis, MN

1991-1992

Fellowship, Rheumatology

University of Washington

Seattle, WA

1992-1995

Contact

Email:

jbuckner@benaroyaresearch.org [2]

Phone:

(206) 287-1033

Mailing Address:

Benaroya Research Institute at Virginia Mason [3]
1201 Ninth Avenue
Seattle, WA 98101

Research & Clinical Interests

Research Interests:

Dr. Buckner’s laboratory is focused on identifying the underlying mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. The diseases studied in Dr. Buckner’s laboratory include type 1 diabetes (T1D), multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosis and relapsing polychondritis. Her laboratory is currently examining the question of how autoreactive T and B cells escape regulation in these diseases and the closely related question of whether the development or function of regulatory T cells is impaired in autoimmunity. Her group uses the genetics of autoimmunity to identify pathways that contribute to the failure of tolerance in these diseases. This work is aided by the availability of human samples for research, which are collected from individuals participating in the Immune Mediated Disease Registry and Repository managed by the Translational Research Program at BRI. This resource provides samples from subjects who are well characterized in terms of clinical characteristics for cellular, biochemical and genetic analysis.

Publications

PubMed:

PubMed Bibliography [4]

Publications:

Selected-

Buckner JH, Nepom GT. (2016) Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes. J Autoimmun. [Epub ahead of print]

Ge Y, Onengut-Gumuscu S, Quinlan AR, Mackey AJ, Wright JA, Buckner JH, Habib T, Rich SS, Concannon P. (2016) Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes. Diabetes. 65:794-802. PMCID:4764149

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. (2016) CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 196:2051-62. PMCID:4761490

Sparks JA, Chang SC, Deane KD, Gan RW, Demoruelle MK, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Holers VM, Norris JM, Karlson EW. (2016) Associations of smoking and age with inflammatory joint signs among first-degree relatives without rheumatoid arthritis: Results from the Studies of the Etiology of RA. Arthritis Rheumatol. [Epub ahead of print]

Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. (2016) Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 55:367-76.

Hamerman JA, Pottle J, Ni M, He Y, Zhang ZY, Buckner JH. (2016) Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases. Immunol Rev. 269:212-27. PMCID:4703580

Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. (2015) Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 7:315ra189. PMCID:4729454