Education & Training:
BS-Biology Duke University Durham, NC (1997)
PhD- Biomedical Sciences, University of California, San Francisco (2002)
Postdoctoral Fellow- Immunology, Yale University, New Haven, CT (2003-2008)
Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All organisms have viral pathogens, and an ancient and fundamental mechanism for detecting viral infection makes use of sensors that recognize viral nucleic acids. In vertebrates, these sensors coordinate an inducible antiviral response by activating the production of type I interferons (IFNs). While the pleiotropic roles of IFNs have been studied since their discovery over five decades ago, recent advances have allowed us to understand their means of induction and complex regulation at a molecular level.
Gray EE, Winship D, Snyder JM, Child SJ, Geballe AP, Stetson DB. 2016. The AIM2-like receptors are dispensable for the interferon response to intracellular DNA. Immunity, In Press.
Pestal K, Funk CC, Snyder JM, Price ND, Treuting PM, Stetson DB. 2015. Isoforms of the ADAR1 RNA editing enzyme independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development. Immunity, 43(5):933-944. NIHMS ID: 736550.
Lau L, Gray EE, Brunette RL, Stetson DB. 2015. DNA tumor virus oncogenes antagonize the cGAS-STING DNA sensing pathway. Science, 350(6260):568-571.
Gray EE, Treuting PM, Woodward JJ, Stetson DB. 2015. cGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of Aicardi-Goutieres Syndrome. Journal of Immunology, 195(5):1939-1943.
Eckard SC, Rice GI, Fabre A, Badens C, Gray EE, Hartley JL, Crow YJ, Stetson DB. 2014. The SKIV2L RNA exosome limits activation of the RIG-I-like receptors. Nature Immunology, 15(9):839-845. NIHMS ID: 609228.
Volkman HE, Stetson DB. 2014. The enemy within: endogenous retroelements and autoimmune disease. Nature Immunology, 15(5):415-422. NIHMS ID: 608398.