Christian
Lood
PhD
Education & Training:
MSc in Biomedicine, Lund University , Sweden (2003-2007)
PhD in Rheumatology, Lund University , Sweden (2008-2012)
Postdoctoral Associate, Lund University, Sweden (2012-2013)
Visiting Scientist, University of Washington, Seattle, WA (2013-2016)
Research Interests:
Dr. Christian Lood studies the role of innate immunity in inflammation and autoimmunity, with an emphasis on the role of neutrophils and mitochondria in the systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and juvenile dermatomyositis (JDM) pathogenesis.
Dr. Lood’s Lab is currently pursuing three main research aims, a) investigating the role of innate immune biomarkers in stratifying patients based on disease activity, disease phenotype and treatment responses; b) determining mechanisms of mitochondrial clearance and inflammation; and c) investigating the role of neutrophils in regulating autoimmunity and inflammation
PubMed:
Publications:
Selected-
Duvvuri B, Pachman LM, Hermanson P, Wang T, Moore R, Ding-Hwa Wang D, Long A, Morgan GA, Doty S, Tian R, Sancak Y, Lood C. Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis. J Autoimmun 2023;138:103061.
Duvvuri B, Baddour AA, Deane KD, Feser ML, Nelson JL, Demoruelle MK, Lood C. Mitochondrial N-formyl methionine peptides associate with disease activity as well as contribute to neutrophil activation in patients with rheumatoid arthritis. J Autoimmun 2021;119:102630.
Duvvuri B, Pachman LM, Morgan G, Khojah AM, Klein-Gitelman M, Curran ML, Doty S, Lood C. Neutrophil extracellular traps in tissue and periphery in juvenile dermatomyositis. Arthritis Rheum 2020;72:348-358.
Bach M, Moon J, Moore R, Pan T, Nelson JL, Lood C. A neutrophil activation biomarker panel in prognosis and monitoring of patients with rheumatoid arthritis. Arthritis Rheum 2020;72:47-56.
Lood C, Arve S, Ledbetter J, Elkon KB. TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA. J Exp Med 2017;214:2103-2119.
Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med 2016;2:146-53.